Prevalence of Hepatitis B Virus Markers in Blood Donors at Hayatabad Medical Complex Peshawar, Pakistan
Keywords:Prevalence, HBV markers, blood donors, Hepatitis
This study aimed to find out the prevalence of Hepatitis B Virus (HBV), and the ratio among the Hepatitis B Virus markers, including Hepatitis B surface Antigen (HBsAg), Hepatitis B surface Antibody (HBsAb), Hepatitis B envelop Antigen (HBeAg), Hepatitis B envelop Antibody and Hepatitis B core Antibody.
A cross-sectional study was conducted from February to July 2022. Three hundred sixty blood donors were selected at Medical Teaching Institute Hayatabad Medical Complex Peshawar, Pakistan. The information about donors was received through a predesigned questionnaire.
The prevalence of HBV marker HBsAg was 2.8%, with the highest reactivity followed by HBcAb at 2.2% and HBeAb at 1.1%. Among HBV markers, no reactivity founded in HBsAb and HBeAg.
The highest positivity reactivity rate was found in HBsAg among HBV markers, while the second and third prevalent markers were HBcAb and HBeAb among blood donors.
Mekonnen D, Solomon T, Nigatu M. Prevalence of Hepatitis B virus and its predictors among volunteer blood donors in Jimma, Ethiopia, 2018: A cross-sectional study. Journal of Clinical Virology Plus. 2022 Nov 4:100122
Liang N, Yang GL, Zhang Z, Liu Y, Yang Y, Liu YX, Wang QG, Zhang F, Zhang HY, Nikolova D, Jakobsen JC. Acupuncture for chronic hepatitis B. The Cochrane Database of Systematic Reviews. 2019 Aug;2019(8)
Koç DÖ, Özhan Y, Acar ET, Bireroğlu N, Aslan F, Keğin M, Sipahi H. Serum neopterin levels and IDO activity as possible markers for presence and progression of hepatitis B. Pteridines. 2020 Jan 1;31(1):91-9
Chen BF. Hepatitis B virus pre-S/S variants in liver diseases. World journal of gastroenterology. 2018 Apr 14;24(14):1507
Zhao K, Liu A, Xia Y. Insights into hepatitis B virus DNA integration-55 years after virus discovery. The Innovation. 2020 Aug 28;1(2):100034
Hashemi SM, Hashemzadeh F, Bahrampour H, Nekoei F, Joharinia N, Sarvari J. The evaluation anti-HBsAb titer among university students in Shiraz, 2019. Iranian Journal of Medical Microbiology. 2020 Jul 10;14(4):297-306
Ansa GA, Ofori KN, Houphouet EE, Amoabeng AA, Sifa JS, Amenuveve CK, Odame GH. Hepatitis B vaccine uptake among healthcare workers in a referral hospital, Accra. The Pan African Medical Journal. 2019;33
Yizengaw E, Getahun T, Geta M, Mulu W, Ashagrie M, Hailu D, Tedila S. Sero-prevalence of hepatitis B virus infection and associated factors among health care workers and medical waste handlers in primary hospitals of North-west Ethiopia. BMC research notes. 2018 Dec;11(1):1-6
Abebe M, Alemnew B, Biset S. Prevalence of hepatitis B virus and hepatitis C virus among blood donors in nekemte blood bank, Western Oromia, Ethiopia: retrospective 5 years study. Journal of blood medicine. 2020;11:543
Ying C, Li Y, Leung CH, Robek MD, Cheng YC. Unique antiviral mechanism discovered in anti-hepatitis B virus research with a natural product analogue
Fabrizi F, Cerutti R, Ridruejo E. Hepatitis B virus infection as a risk factor for chronic kidney disease. Expert review of clinical pharmacology. 2019 Sep 2;12(9):867-74
Seto WK, Lo YR, Pawlotsky JM, Yuen MF. Chronic hepatitis B virus infection. The Lancet. 2018 Nov 24;392(10161):2313-24
Im YR, Jagdish R, Leith D, Kim JU, Yoshida K, Majid A, Ge Y, Ndow G, Shimakawa Y, Lemoine M. Prevalence of occult hepatitis B virus infection in adults: a systematic review and meta-analysis. The Lancet Gastroenterology & Hepatology. 2022 Aug 10
Yang YW, Chen CC, Yang CY, Lee CY, Yang HC, Chiang BL, Chuang YH, Wu TE, Lai HS, Tsai MK. Dynamics of cellular immune responses in recipients of renal allografts positive for hepatitis B surface antigen. Journal of the Formosan Medical Association. 2022 May 1;121(5):958-68.
de Almeida Pondé RA. Detection of the serological markers hepatitis B virus surface antigen (HBsAg) and hepatitis B core IgM antibody (anti‐HBcIgM) in the diagnosis of acute hepatitis B virus infection after recent exposure. Microbiology and Immunology. 2022 Jan;66(1):1-9.
Al-Rawazq HS. Hepatitis B Virus (HBV): A Review on its Prevalence and Infection in different areas of Iraq. Journal of Advanced Laboratory Research in Biology. 2020
Mohammed HI, Pennap GR, Oti VB, Adoga MP. Markers of hepatitis B virus infection in a subset of young people in central Nigeria. Scientific African. 2019 Sep 1;5:e00121
Boumbaly S, Balde TA, Semenov AV, Ostankova YV, Serikova EN, Naidenova EV, Valutite DE, Shchemelev AN, Zueva EB, Esaulenko EV, Totolian AA. Prevalence of viral hepatitis B markers among blood donors in the Republic of Guinea. Problems of Virology. 2022 Mar 15;67(1):59-68
Alzubiery TK, Alhazari T, Alcantara JC, Majed SA, Bazaid AS, Aldarhami A. Updated Seroprevalence of Hepatitis B Surface Antigen and Anti-Hepatitis Core Antibody Among Blood Donors in Yemen. Infection and Drug Resistance. 2022; 15:2787